Progress on T lymphocytes in pediatric inflammatory bowel disease
10.3760/cma.j.issn.1673-4408.2024.10.001
- VernacularTitle:T细胞在儿童炎症性肠病中的研究进展
- Author:
Yan KONG
1
;
Tianzhuo ZHANG
;
Jie WU
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院消化科100045
- Keywords:
Children;
T lymphocytes;
Inflammatory bowel disease
- From:
International Journal of Pediatrics
2024;51(10):649-653
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of pediatric inflammatory bowel disease（PIBD）is on the rise globally，leading to a significant disease burden.While there is some comprehension of PIBD's causes，the precise mechanisms remain uncertain.Recent studies have increasingly focused on the interplay of genetic susceptibility，environmental factors，and immune response，with particular emphasis on the involvement of T lymphocytes.Investigating the activation，migration and response patterns of T lymphocytes in PIBD holds promise for identifying potential biomarkers and therapeutic targets.This exploration could offer fresh insights for early detection and personalized treatment strategies for children with IBD.This article reviews the pivotal role of T lymphocytes in the development of PIBD，their connection to genetic mutations，and their utility in clinical monitoring，in order to enhance the understanding of PIBD's pathogenesis，and provide reference for both basic research and clinical applications.
