Recent Advances in Nanozymes with Hydrolase-like Activity for Sensing Application
10.19756/j.issn.0253-3820.241255
- VernacularTitle:水解纳米酶的类酶催化及传感应用研究进展
- Author:
Wen-Xuan JIANG
1
;
Yu WU
;
Wei-Qing XU
;
Ying ZHOU
;
Cheng-Zhou ZHU
;
Yue-He LIN
Author Information
1. 华中师范大学化学学院,绿色农药全国重点实验室,智能生物传感技术与健康国际联合研究中心,武汉 430079
- Keywords:
Nanozymes;
Biomimetic catalysis;
Hydrolase-like activity;
Sensing;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(10):1435-1445
- CountryChina
- Language:Chinese
-
Abstract:
As a new type of artificial enzyme,hydrolytic nanozymes possess both hydrolase-like catalytic activity and unique physicochemical properties,enabling them to overcome the limitations of natural enzymes in practical applications and foster the development of new application scenarios.The rise of biomimetic catalysis has inspired the design and development of various nanozymes with hydrolase-like activities.However,due to the complexity of the catalytic mechanism of natural enzymes,accurately mimicking multiple cofactors remains a great challenge.This article summarized the latest research progress in nanozymes with hydrolase-like activity for sensing applications.First,inspired by the catalytic mechanism of natural hydrolase,the recent advances in the bionic design of hydrolytic nanozymes were introduced,highlighting two key cofactors:metal sites and amino acid microenvironments.Then,the sensing applications for detection of pesticides,ions,and biomolecules were summarized,and the current opportunities and challenges were described.
