Advances in Single Particle Inductively Coupled Plasma-Mass Spectrometry Analysis of Silver Nanoparticles in Biological Matrices
10.19756/j.issn.0253-3820.241180
- VernacularTitle:单颗粒电感耦合等离子体质谱技术用于生物基质中纳米银检测的研究进展
- Author:
Guo-Hui XING
1
;
Li-Hong LIU
;
Jun-Hui ZHANG
;
Bin HE
;
Yong-Guang YIN
;
Li-Gang HU
;
Gui-Bin JIANG
Author Information
1. 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085;中国科学院大学,北京 100085
- Keywords:
Single particle-inductively coupled plasma-mass spectrometry;
Silver nanoparticles;
Biological matrix;
Pretreatment;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(10):1413-1423
- CountryChina
- Language:Chinese
-
Abstract:
Silver nanoparticles(AgNPs)is widely used in biomedicine,daily chemicals,food industry and other fields,and the possible negative health effects of its exposure have attracted widespread attention.Accurate analysis of AgNPs in biological matrices is the basis for biosafety studies of AgNPs.Among the existing analytical techniques,single particle-inductively coupled plasma-mass spectrometry(sp-ICP-MS)has significant advantages such as high sensitivity and simultaneous detection of different forms of silver.However,AgNPs in biological matrices is uniquely highly dynamic and low in content,and the matrix interference is severe,which increases the complexity of the analysis.Although some scholars have reviewed the application of this method for detection of metal nanoparticles in different scenarios,there is a lack of a summary of the quality control and optimization of the whole process from the perspective of AgNPs detection.There is still a lack of reference standards for the sp-ICP-MS analysis of AgNPs in biological matrices,and the existing methods need to be summarized and further optimized to achieve accurate quantification.Therefore,this paper reviewed the recent studies on the analysis of silver-containing nanoparticles in biological matrices based on sp-ICP-MS,mainly included the principles of the technique,the extraction methods of the particles,and the process of data processing,which focused on elaborating and comparing different pre-treatment methods,and explored issues of the current application of sp-ICP-MS for detection of AgNPs in biological tissues and the development of future optimization trends.The current problems of sp-ICP-MS for detection of AgNPs in biological tissues and the future development trend were also discussed.
