Injectable Fluorescent Bi2S3/Au Nanoclusters Hydrogel for Postoperative Photothermal Therapy of Tumor and Promoting Wound Healing
10.19756/j.issn.0253-3820.241220
- VernacularTitle:可注射荧光硫化铋/金纳米簇水凝胶用于肿瘤术后光热治疗和促进伤口愈合性能分析
- Author:
Zhuo LI
1
;
Shao-Xian YANG
;
Rui LIU
;
Zheng-Lin YANG
;
Yu-Yu CAO
;
Hong-Mei SUN
Author Information
1. 湖北工业大学生命科学与健康工程学院,发酵工程教育部重点实验室,国家细胞调控与分子药物"111"引智基地,工业微生物湖北省重点实验室,湖北省工业发酵协同创新中心,武汉 430068
- Keywords:
Multifunctional hydrogel;
Bismuth sulfide-gold nanocluster nanoparticles;
Photothermal therapy;
Fluorescence;
Postoperative wounds
- From:
Chinese Journal of Analytical Chemistry
2024;52(7):955-963
- CountryChina
- Language:Chinese
-
Abstract:
Herein,a new multifunctional hydrogel wound dressing was fabricated for the first time based on the crosslinking between catechol-modified chitosan(CHI-C)and bismuth sulfide-gold nanocluster nanoparticles(Bi2S3-Au NCs NPs)by simple stirring at room temperature within 1 min.Benefit from the good biocompatibility of CHI-C and excellent photothermal abilily of Bi2S3-Au NCs NPs,it could achieve postoperative photothermal therapy of tumor residual tissue and wound healing.More importantly,the as-prepared hydrogel with fluorescent property could accurately monitor the postoperative wound filling in real-time,which was critical to wound healing,especially for irregular wounds.The smart hydrogel was expected to provide a new perspective for preventing and reducing cancer recurrence and wound infection after surgery.
