Magnetic Multi-Walled Carbon Nanotubes Nanomaterials as Magnetic Solid Phase Extraction Adsorbents for Simultaneous Determination of Multiple Mycotoxins in Agricultural Products by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
10.19756/j.issn.0253-3820.241038
- VernacularTitle:基于磁性多壁碳纳米管的磁性固相萃取-超高效液相色谱-串联质谱法测定农产品中22种真菌毒素
- Author:
Shuai MA
1
;
Gang LIANG
;
Yan MAN
;
Xin-Xin JIN
;
An LI
Author Information
1. 北京市农林科学院质量标准与检测技术研究所,北京 100097
- Keywords:
Mycotoxins;
Magnetic multi-walled carbon nanotubes;
Magnetic solid-phase extraction;
Ultra-high performance liquid chromatography-tandem mass spectrometry
- From:
Chinese Journal of Analytical Chemistry
2024;52(4):550-558
- CountryChina
- Language:Chinese
-
Abstract:
A simple,rapid and efficient magnetic solid-phase extraction(MSPE)method was established by employing magnetic multi-walled carbon nanotubes(Fe3O4-MWCNTs)as adsorbents.And further,by coupling with ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS),an accurate quantitative approach for analysis of 22 kinds of mycotoxins in agricultural products was developed.With Fe3O4-MWCNTs as MSPE adsorbents,the enrichment efficiency of various target fungal toxins was improved and the sample pretreatment time was reduced effectively.In the pre-treatment stage,the extraction solution,adsorbent type,adsorbent dosage and elution solution type were systematically optimized.Under the optimal pre-treatment conditions of MSPE,the methodological investigation of the method was carried out.Under the optimal conditions,the proposed method showed a good linearity(R2≥0.9966),high sensitivity(The limits of detection(S/N=3)were 0.0008-1.6337 ng/g and the limits of quantification(S/N=10)were 0.0025-5.4457 ng/g),adequate recoveries(71.5%-118.4%),and good repeatability(Intra-day precision in the range of 1.3%-10.9%and inter-day precision in the range of 2.3%-11.6%).The improved MSPE-UPLC-MS/MS analytical method had advantages inculding simplicity,rapidity and high efficiency,and could realize simultaneous detection of multiple mycotoxins in large quantities of agricultural products.
