A comparative study on efficacy of glucocorticoids in patients suffering acute low-tone sensorineural hearing loss
10.16066/j.1672-7002.2024.06.005
- VernacularTitle:糖皮质激素治疗急性低频感音神经性聋疗效的对比分析
- Author:
Chenghui ZHANG
1
Author Information
1. 郑州大学第五附属医院耳鼻咽喉科,河南 郑州 450052
- Keywords:
Deafness;
Hearing Loss,Sensorineural;
Glucocorticoids;
acute low-tone sensorineural hearing loss;
electrocochleograms
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(6):360-363
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the therapeutic role of glucocorticoids in acute low-tone sensorineural hearing loss and to guide clinical management.METHODS Recorded electrocochleograms in 200 ears.Based on the results,these patients were divided into-SP/AP≥0.4 with 110 ears and-SP/AP<0.4 with 90 ears.In a randomized,single-blind fashion,the two groups were divided into systemic,local,and non-glucocorticoid-treated groups separately.We compared treatment effects between different groups.RESULTS The-SP/AP ratios are abnormally increased in 55%of ALHL patients.In patients with-SP/AP≥0.4,the effective treatment rates of systemic,local and non-glucocorticoid groups were 92.50%,94.59%and 72.73%,respectively.A comparison between systemic and local glucocorticoid delivery regimes,P>0.05,and the two groups were compared with the non-glucocorticoid group,P≤0.05.In patients with-SP/AP<0.4,compared the efficacy of the three groups,P>0.05.CONCLUSION In patients with-SP/AP≥0.4,glucocorticoids are more effective than non-glucocorticoid,systemic glucocorticoids are as effective as local glucocorticoids.In patients with-SP/AP<0.4,In contrast,systemic,local and non glucocorticoids are equally effective.
