Construction and validation of cuproptosis-related genes prognostic model for oral squamous cell carcinoma
10.3969/j.issn.1671-8348.2024.22.013
- VernacularTitle:口腔鳞状细胞癌患者铜死亡相关基因预后模型的构建和验证
- Author:
Kai HUANG
1
;
Junfeng GUO
;
Huan LIU
;
Gang ZHANG
Author Information
1. 陆军军医大学第二附属医院口腔科,重庆 400037
- Keywords:
cuproptosis;
oral squamous cell carcinoma;
TCGA database;
prognosis;
model
- From:
Chongqing Medicine
2024;53(22):3435-3440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct and verify the prognostic risk model for cuproptosis-related genes in oral squamous cell carcinoma(OSCC).Methods The clinical and transcriptomic data of OSCC patients were downloaded from the Cancer Genome Atlas(TCGA)database.The cuproptosis-related genes in the patients with OSCC were screened out.The cuproptosis-related genes risk model was constructed by the coexpression analysis,Wilcoxon rank sum test,Cox analysis and AIC step-by-step algorithm.Then its accuracy was evalua-ted.Results A total of 340 cases of OSCC were screened out and served as the training group and internal verification group.A total of 24 cases served as the external verification group.The cuproptosis-related genes risk model in the patients with OSCC was successfully constructed.This model was composed of cyclin de-pendent kinases regulatory subunit 2(CKS2),tetratricopeptide repeat domain 21A(TTC21A)and zinc fin-ger,MYND-type containing 10(ZMYND10)copper death-related genes.The area under the receiver operating characteristic(ROC)curve(AUC)was 0.710,possessing the ideal predictive performance.Among them,the prognosis in the OSCC patients with high risk score was relatively poor.In addition,the above model score was an independent influencing factor for the prognosis in OSCC patients(HR=1.472,95％CI:1.141-1.899,P=0.003).Conclusion The constructed model could provide the reliable basis for the diagnosis,treat-ment and prognosis evaluation in the patients with OSCC.
