Research progress of lncRNA PVT1 in cardiovascular diseases
10.3969/j.issn.1671-8348.2024.18.024
- VernacularTitle:lncRNA PVT1在心血管疾病中的研究进展
- Author:
Shuang LIU
1
;
Bofang ZHANG
;
Jing CHEN
Author Information
1. 武汉大学人民医院心血管内科/武汉大学心血管病研究所/心血管病湖北省重点实验室,武汉 430060
- Keywords:
lncRNA PVT1;
cardiovascular disease;
diagnosis;
treat;
review
- From:
Chongqing Medicine
2024;53(18):2854-2859
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is one of the leading causes of death and health burden worldwide,se-riously affects the life quality of the patients.Therefore,it is essential to seek early identification,diagnosis and effective treatment method.At present,a large number of studies have shown that lncRNA is involved in the regulation of tumors,cardiocerebrovascular diseases and immune diseases through ceRNA and other mech-anisms.Among them,lncRNA plasmacytoma variant translocation gene 1 (PVT1) may become an important detection and therapeutic target by promoting fibrosis proliferation,inflammation,apoptosis,mitochondrial metabolism and other pathways to aggravate cardiac damage.However,the current research is scattered,and some of the research conclusions are different.Therefore,this article reviewed the latest research progress of lncRNA PVT1 in cardiovascular diseases,in order to provide a more comprehensive theoretical basis for basic research and clinical practice of cardiovascular diseases.
