Analysis of reflux impedance monitoring characteristics of gastroesophageal reflux disease in children
10.3969/j.issn.1671-8348.2024.16.018
- VernacularTitle:儿童胃食管反流病的反流阻抗监测特点分析
- Author:
Yang XU
1
;
Yabin WU
Author Information
1. 湖北医药学院湖北省妇幼保健院培养基地,武汉 430070
- Keywords:
children;
gastroesophageal reflux disease;
24 h esophageal multichannel intracavitary impedance-pH;
gas reflux;
upright position reflux
- From:
Chongqing Medicine
2024;53(16):2492-2495,2502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of reflux and reflux impedance in children patients with gastroesophageal reflux disease (GERD) based on 24 h esophageal multichannel intracavitary impedance-pH (24 h MII-pH) monitoring technology,and to investigate the pathological injury mechanism possibly cau-sing extraesophageal symptoms.Methods The clinical data of 255 children patients with GERD visited and treated in this hospital from September 2019 to March 2023 were analyzed retrospectively.24 h MII-pH was used to monitor the various indexes of children patients with GERD.The reflux characteristics were analyzed,including different natures of reflux objects (liquid,gas,mixture),acidity (acid,weak acid,acid-free),position (upright position,supine position) and impedance monitoring data at highest impedance position (15 cm height from the cardia).Results Among 255 children patients,223 cases (88.5％) had the respiratory symp-toms as the initial onset.A total of 155 children patients completed the 24 h MII-pH monitoring and obtained the report.According to the Boix-Ochoa comprehensive score>11.99 points and acid exposure time percent-age (AET)>4％,the children patients were divided into the acid reflux positive group (GERD group,n=83) and acid reflux negative group (non-GERD group,n=72),and the gastric acid reflux positive rate was 53.6％.Whether or not having gas reflux,the times of acid reflux impedance in the GERD group were more than those in the non-GERD group (P<0.05);when the gas reflux existed,the reflux impedance times of weak acid and non-acid in the GERD group were less than those in the non-GERD group (P<0.05).When the reflux of different liquids,gases,mixed and acid reflux,the reflux impedance times of the upright position were more than those of supine position (P<0.05).The reflux impedance times of acid,upright position and supine position in the GERD group were more than those in the non-GERD group (P<0.05).The total reflux impedance times had no statistical difference between the two groups (P>0.05).Conclusion Gas reflux may play an extremely important role in GERD children with extragastrointestinal symptoms as the main manifes-tations.
