Research progress of Siglec in immune regulatory mechanisms of liver transplantation
10.3969/j.issn.1671-8348.2024.13.025
- VernacularTitle:Siglec在肝移植免疫调控机制中的研究进展
- Author:
Jiefu LUO
1
;
Jianping GONG
;
Mingxiang CHENG
Author Information
1. 重庆医科大学附属第二医院肝胆外科,重庆 400010
- Keywords:
sialic-binding immunoglobulin-like lectin;
liver transplantation;
immune tolerance;
immune rejection;
ischemia reperfusion;
review
- From:
Chongqing Medicine
2024;53(13):2059-2064
- CountryChina
- Language:Chinese
-
Abstract:
In various immunomodulatory systems,there exists a transmembrane receptor expressed on the surface of immune cells,which can play a role selectively,namely the sialic-binding immunoglobulin-like lectin(Siglec)family.Inhibition of host T cell antigen response is a key factor in inducing immune tolerance of liver transplantation.Recently,Siglec-15 has been found to be an important T cell suppressor molecule,and some of its family members have similar structure and biological characteristics.It is speculated that the mem-bers of Siglec family may be a new target for inducing liver immune tolerance.Therefore,this paper reviews the relevant literatures in this field,and takes Siglec-15 as the entry point to explore the possible role and mo-lecular mechanism of Siglec family in inhibiting host T cell antigen response and regulating immune response in order to provide the new ideas for the establishment of immune regulation and tolerance after transplanta-tion.
