Hemodynamic effects of ciprofol on the anesthetic induction period of mitral valve replacement surgery under cardiopulmonary bypass
10.3969/j.issn.1671-8348.2024.09.011
- VernacularTitle:环泊酚对体外循环下二尖瓣置换术麻醉诱导期的血流动力学影响
- Author:
Bo SONG
1
;
Yonghong ZHANG
;
Jun LI
;
Jian PENG
;
Yutao HU
Author Information
1. 绵阳市麻醉科与神经调控重点实验室/绵阳市中心医院麻醉科,四川绵阳 621000
- Keywords:
ciprofol;
induction;
mitral valve replacement;
hemodynamics
- From:
Chongqing Medicine
2024;53(9):1339-1343
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of ciprofol and propofol on hemodynamics and cardiac work were determined by hemodynamic monitoring,so as to provide reference for anesthesia induction in car-diac surgery.Methods A total of 90 patients scheduled for mitral valve replacement under cardiopulmonary bypass from June 2022 to June 2023 were randomly divided into two groups:the ciprofol group (group P,n=45) and the propofol group (group B,n=45).The heart rate (HR),oxygen saturation (SpO2),index of con-sciousness (ICO1),mean arterial pressure (MAP),central venous pressure (CVP),stroke volume (SV),car-diac output (CO),systemic vascular resistance (SVR),cardiac cycle efficiency (CCE),stroke volume variation (SVV),maximum pressure gradient reflecting myocardial contractility (dp/dt) were recorded before adminis-tration (T0) and five min after administration (T1).Results In group P,ICO1,MAP,SV,CO,and SVR at T1 were lower than those at T0,and CCE was higher than that at T0 (P<0.01,P<0.05).In group B,ICO1, MAP,CVP,SV,CO,SVR,CCE,SVV,dp/dt at T1 were significantly lower than those at T0 (P<0.01,P<0.05).There was no statistically significant difference in HR,SpO2,ICO1,MAP,CVP and hemodynamic indi-cators between group B and group P at T0 (P>0.05).There was no statistically significant difference in HR, SpO2,ICO1,CVP and SVV between group B and group P at T1 (P>0.05).MAP,SV,CO,SVR,CCE and dp/dt at T1 in group P were higher than those in group B (P<0.05).Conclusion Ciprofol can better maintain hemodynamic stability and reduce cardiac impairment during the induction phase of mitral valve replacement surgery under cardiopulmonary bypass.
