Autophagy regulation and therapeutic potential of mesenchymal stem cells-derived exosomes in diabetic nephropathy

VernacularTitle:间充质干细胞源性外泌体在糖尿病肾病中的自噬调节和治疗潜力
Author: Lili WU ¹ ; Jincheng ZENG
Author Information

1. 广东医科大学医学技术学院/广东省医学分子诊断重点实验室,广东东莞 523808;东莞市大朗医院检验科,广东东莞523770
Keywords: diabetic nephropathy; mesenchymal stem cells-derived exosomes; autophagy
From: Chongqing Medicine 2024;53(9):1281-1288
CountryChina
Language:Chinese
Abstract: Diabetic nephropathy (DN) is one of the complications of diabetes mellitus,which is accom-panied by severe microvascular lesions.and is also the most common inducing factor of end-stage chronic kid-ney disease.The traditional treatment of DN cannot fundamentally cure diabetes and its complications,and new treatment methods need to be explored urgently.At present,the diagnosis and treatment strategy of using mesenchymal stem cells-derived exosomes (MSCs-exo) has become a research hotspot in the early diagnosis and clinical treatment of DN.A number of studies have confirmed that MSCs-exo has high efficacy and safety in the treatment of DN,and MSCs-exo plays a renoprotective role in diabetic nephropathy models by transfer-ring its own contents to the damaged tissue.This article focuses on the research progress and therapeutic po-tential of mesenchymal stem cell-derived exosomes in regulating autophagy in diabetic nephropathy,in order to provide new ideas and methods for the treatment of DN.