Progress of circulating tumor cells in multiple myeloma

VernacularTitle:循环肿瘤细胞在多发性骨髓瘤中的研究进展
Author: Lingna LI ¹ ; Gang AN ; Lugui QIU
Author Information

1. 中国医学科学院血液病医院（中国医学科学院血液学研究所）淋巴瘤诊疗中心　实验血液学国家重点实验室　国家血液系统疾病临床医学研究中心　细胞生态海河实验室，天津　300020
Keywords: Leukemia, plasma cell; Multiple myeloma; Circulating tumors cells; Immunotherapy; Prognosis
From: Journal of Leukemia & Lymphoma 2024;33(5):306-309
CountryChina
Language:Chinese
Abstract: Circulating tumor cells (CTC) are tumor cells that are shed from primary or secondary lesions of tumors and enter the blood. Although multiple myeloma (MM) is characterized by malignant proliferation of plasma cells in the bone marrow, it is also a hematologic malignancy with a systemic distribution of tumor cells. Circulating multiple myeloma cells (CMMC) can be widely detected in MM patients and can represent the clonality and invasiveness of MM cells themselves. In recent years, with the continuous improvement of detection technology and the deepening of understanding, CTC detection has shown good clinical application prospects in the study of MM. This article reviews the research progress of isolation and identification of CMMC and its application in diagnosis and prognosis of MM.