Emerging mechanisms of ferroptosis and its implications in lung cancer
10.1097/CM9.0000000000003048
- VernacularTitle:Emerging mechanisms of ferroptosis and its implications in lung cancer
- Author:
Qian LI
1
;
Qibin SONG
;
Huadong PEI
;
Yali CHEN
Author Information
1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China
- Keywords:
Lung cancer;
Ferroptosis;
Ferroptosis regulators;
Ferroptosis inducers;
Cancer treatment
- From:
Chinese Medical Journal
2024;137(7):818-829
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most common malignancies and has the highest number of deaths among all cancers. Despite continuous advances in medical strategies, the overall survival of lung cancer patients is still low, probably due to disease progression or drug resistance. Ferroptosis is an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides, and its dysregulation is implicated in cancer development. Preclinical evidence has shown that targeting the ferroptosis pathway could be a potential strategy for improving lung cancer treatment outcomes. In this review, we summarize the underlying mechanisms and regulatory networks of ferroptosis in lung cancer and highlight ferroptosis-targeting preclinical attempts to provide new insights for lung cancer treatment.
