Immune cells in the B-cell lymphoma microenvironment: From basic research to clinical applications
10.1097/CM9.0000000000002919
- VernacularTitle:Immune cells in the B-cell lymphoma microenvironment: From basic research to clinical applications
- Author:
Wenli ZHANG
1
;
Mengmeng LIU
;
Wei LI
;
Yongping SONG
Author Information
1. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
- Keywords:
Tumor microenvironment;
B-cell lymphoma;
Immune cells;
Immunotherapy;
Targeted therapy
- From:
Chinese Medical Journal
2024;137(7):776-790
- CountryChina
- Language:Chinese
-
Abstract:
B-cell lymphoma is a group of hematological malignancies characterized by variable genetic and biological features and clinical behaviors. The tumor microenvironment (TME) is a complex network in tumors, which consists of surrounding blood vessels, extracellular matrix, immune and non-immune cells, and signaling molecules. Increasing evidence has shown that the TME, especially immune cells within, is a double-edged sword, acting either as a tumor killer or as a promoter of tumor progression. These pro-tumor activities are driven by subpopulations of immune cells that express typical markers but have unique transcriptional characteristics, making tumor-associated immune cells good targets for human anti-cancer therapy by ablating immunosuppressive cells or enhancing immune-activated cells. Thus, exploring the role of immune cells in the TME provides distinct insights for immunotherapy in B-cell lymphoma. In this review, we elucidated the interaction between immune cells and tumor cells and their function in the initiation, progression, and prognosis of B-cell lymphoma, from preclinical experiments to clinical trials. Furthermore, we outlined potential therapeutic approaches and discussed the potential clinical value and future perspectives of targeting immune cells in patients with B-cell lymphoma.
