Basaloid squamous cell carcinoma of the esophagus：an immunohistochemical study of 8 cases
10.3760/j.issn:0366-6999.2001.10.018
- VernacularTitle:8例食管基底细胞样鳞状细胞癌的免疫组化研究
- Author:
ZZ HUANG
1
;
YQ SHEN
;
YR LIANG
;
XY WU
Author Information
1. Shantou University Medical College
- From:
Chinese Medical Journal
2001;114(10):1084-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the biological features of basaloid squamous cell carcinoma (BSC) of the esophagus. Methods Cytokeratins (CK4, CK18 and CK19), epithelial membrane antigen (EMA), carcino embryo antigen (CEA), α-smooth muscle antigen (α-SMA), S-100, laminin (LN), collagen Ⅳ (Col-Ⅳ), neural specific enolase (NSE), proliferating cell nuclear antigen (PCNA) and p53 antibodies were used to detect the corresponding antigen expression in 8 cases of BSC with ABC immunohistochemical methods. Results Two kinds of BSC cell components have different responses to the above antibodies. For basaloid cells (BCs), 7 cases were positive for CK19, and were negative for the other 4 epithelial antibodies CK4, CK18, CEA and EMA. BCs of 4 cases were positive to the muscular antibodies α-SMA and S-100, and the hyaline degeneration in the tumor nests was positive for LN and Col-Ⅳ. BCs had a high index of PCNA, with an average level of 54%. For squamous cells (SCs), 7 cases were positive for the epithelial antigen CK4, CEA and EMA, but were negative for CK19, α-SMA and S-100. The index of PCNA of SC was low, with an average level of 25%. Conclusion BSC of the esophagus is a high-malignancy tumor which is of multi-oriented differentiation. BCs represent basal cells which have the tendency of myoepithelial differentiation and have strong proliferation ability, whereas SCs represent typical squamous cell differentiation.
