Novel chromosomal alterations detected in primary nasopharyngeal carcinoma by comparative genomic hybridization

Keywords: nasopharyngeal carcinoma; comparative genomic hybridization; chromosomal alteration原发性鼻咽癌新的遗传学改变鄢践方嬿梁启万黄贻学曾益新
From: Chinese Medical Journal 2001;114(4):418-421
CountryChina
Language:Chinese
Abstract: Objective To gain a better understanding of genetic changes inCantonese nasopharyngeal carcinoma (NPC). Methods Comparative genomic hybridization (CGH) was performed on 17 primary nasopharyngeal carcinomas. Results A novel copy number gain an chromosome 4q and loss of chromosome 1p were found at a high frequency (>50%). Conclusions Current analysis revealed a comprehensive profile of the chromosomal regions showing gain of chromosomes 4q, 12q, and 1q as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.