Frequency of loss expression of the DPC4 protein in various locations of biliary tract carcinoma

VernacularTitle:DPC4蛋白在不同部位胆道恶性肿瘤中的缺失表达
Keywords: Biliary tract neoplasms; Immunohist～ochemistry; DPC4 protein
From: Chinese Journal of Surgery 2002;40(7):481-484
CountryChina
Language:Chinese
Abstract: Objective To clarify the relationship between the loss of expression of the deleted in pancreatic carcinoma locus 4 (DPC4) proteins and the pathogenesis of biliary tract carcinoma.Methods 71 primary biliary tract carcinoma (BTCa), including 38 common bile duct (CBD) carcinomas, 18 gallbladder carcinomas, 15 hilar bile ducts (HBD) carcinomas were examined by immunohistochemical staining. In addition, the CBD carcinomas were divided into two groups: tumors with metastasis (M+ group, 27 cases) and tumors without metastasis (M- group, 11 cases).Results The frequency of loss of the expression of DPC4 protein was 32.8% in BTCa, 47.3% in CBD carcinoma, 11% in gallbladder carcinoma, 13% in HBD carcinoma. Comparison of the frequency of loss expression of DPC4 was significant statistical difference in CBD carcinoma versus gallbladder carcinoma and HBD carcinoma (P<0.01). The frequency of loss expression of DPC4 was 48.1% in the M+ group and 45.4% in the M- group.Conclusion There are a close relationship between pathogenesis of BTCa and inactivation of DPC4 and different frequencies of DPC4 gene alternation in various locations of the biliary tract, which are not significantly increased with tumor metastasis in BTCa.