Clinical effect of ambroxol hydrochloride combined with bovine pulmonary surfactant on treatment of premature neonates with respiratory distress syndrome
- VernacularTitle:盐酸氨溴索联合牛肺表面活性物质治疗早产儿呼吸窘迫综合征的临床疗效观察
- Author:
Xiaoqiao LIU
1
;
Rui TU
Author Information
- Keywords: ambroxol hydrochloride; pulmonary surfactant; neonate; respiratory distress syndrome; clinical effect
- From: Journal of Clinical Medicine in Practice 2017;21(15):49-52
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the clinical effect of ambroxol hydrochloride combined with bovine pulmonary surfactant on treatment of premature neonates with respiratory distress syndrome.Methods Totally 50 premature neonates with respiratory distress syndrome were divided into separate application with bovine pulmonary surfactant group (control group) and bovine pulmonary surfactant combined with injection of ambroxol hydrochloride group (observation group).The oxygen partial pressure [p(O2)], carbon dioxide partial pressure [p(CO2)] and calculation of oxygenation index [p(O2)/FiO2] at 1, 12, 24, 48 h after treatment were compared between two groups, and the ventilator treatment time, oxygen therapy time and hospitalization time were observed.Results The p(CO2) levels in the observation group at 12, 24 and 48 h after treatment were significantly lower than those in the control group at the same time points (P<0.05).The p(O2) levels in the observation group at 12, 24 and 48 h after treatment were significantly higher than those in the control group at the same time points (P<0.05).The p(O2)/FiO2 in the observation group were significantly higher than the control group at 12 and 24 h after treatment (P<0.05).The time of ventilator treatment and oxygen therapy time in the observation group were significantly shorter than the control group(P<0.05).Conclusion In treatment of premature neonates with respiratory distress syndrome, ambroxol hydrochloride combined with bovine pulmonary surfactant can effective improve early oxygen partial pressure and oxygen index, reduce partial pressure of carbon dioxide, and shorten auxiliary ventilation and oxygen therapy time.
