Signal mechanism of skin scar hyperplasia induced by mechanical tension
10.3760/cma.j.cn114453-20231026-00141
- VernacularTitle:机械张力诱发皮肤瘢痕增生的信号机制研究进展
- Author:
Min JIANG
1
;
Jiaping ZHANG
Author Information
1. 陆军军医大学（第三军医大学）第一附属医院整形外科 创伤、烧伤与复合伤国家重点实验室，重庆 400038
- Keywords:
Cicatrix;
Hypertrophy;
Mechanical tension;
Signal pathways
- From:
Chinese Journal of Plastic Surgery
2023;39(12):1377-1383
- CountryChina
- Language:Chinese
-
Abstract:
After surgery, scars will inevitably be left at the surgical site. It is very important to understand the influencing factors and mechanism of scars formation to improve postoperative appearance. Mechanical tension is one of the important factors affecting scar formation. In this paper, the effects and signaling mechanisms of mechanical tension on scar formation, such as integrin-cytoskeleton signal pathway, transforming growth factor-β signal pathway, Hippo signal pathway, Rho-related pathway, mechanically sensitive ion channel pathway and so on, were summarized to provide reference for further research.
