Current status of research on the diagnosis and treatment of acute ethylene glycol poisoning

VernacularTitle:急性乙二醇中毒诊治研究现状
Author: Kai YANG ¹ ; Hogahemat Kelaiti· XIAO ; Peng PENG
Author Information

1. 新疆医科大学第一附属医院急救·创伤中心，乌鲁木齐　830011
Keywords: Ethylene glycol; Acute poisoning; Acute kidney injury; Diagnosis Medication therapy; Hemodialysis
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2024;42(10):788-793
CountryChina
Language:Chinese
Abstract: Acute ethylene glycol poisoning often leads to acute kidney injury, and delays in diagnosis and treatment can lead to severe multi-organ dysfunction and even death. At present, there is a lack of specific laboratory tests that can be used for rapid clinical diagnosis, and diagnosis and evaluation only rely on medical history, clinical symptoms, and non-specific laboratory test results. Key treatments include alcohol dehydrogenase inhibitors (fomcpizole or ethanol) and hemodialysis, which is not approved in China. A clear understanding of the mechanism of toxicity, pathophysiology, clinical manifestations, efficacy and limitations of laboratory tests, and treatment options after ethylene glycol poisoning can help accelerate the early diagnosis, treatment, and prognosis of patients after ethylene glycol poisoning. This article reviews this article in order to provide a reference for clinicians.