Research progress on the correlation between small dense low-density lipoprotein-cholesterol and atherosclerotic cardiovascular disease
10.3760/cma.j.cn112150-20210817-00801
- VernacularTitle:小而密低密度脂蛋白胆固醇与动脉粥样硬化性心血管疾病相关性的研究进展
- Author:
Xuesong FAN
1
;
Linlin SHEN
;
Rong HU
;
Jianxun HE
;
Yuantai LI
;
Hui YUAN
Author Information
1. 首都医科大学附属北京安贞医院检验科，北京 100029
- Keywords:
Cholesterol;
Atherosclerosis;
Atherosclerotic cardiovascular disease;
Small dense low-density lipoprotein-cholesterol
- From:
Chinese Journal of Preventive Medicine
2021;55(12):1507-1512
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerotic cardiovascular disease (ASCVD), a series of cardiovascular diseases based on atherosclerosis, has attracted more clinical attention. However, with the increase of population-based research results, the diagnostic value of traditional blood lipid parameters such as low density lipoprotein-cholesterol (LDL-C) is showing limitations. In recent years, a large number of studies have confirmed that small dense low-density lipoprotein cholesterol (sdLDL-C) has lower affinity with low-density lipoprotein receptor, longer circulation time and easier to penetrate arterial endothelium, so it has stronger atherogenic effect. Therefore, we summarize the common detection methods of sdLDL-C, the research progress of the correlation between sdLDL-C and ASCVD risk, as well as the intervention measures and influencing factors of sdLDL-C level, in order to deepen the clinician′s understanding of the role of sdLDL-C in ASCVD and achieve the early prevention, early detection and early diagnosis of chronic atherosclerosis.
