Research progress of cranial suture mesenchymal stem cells in craniosynostosis
10.3760/cma.j.cn114453-20230130-00015
- VernacularTitle:颅缝间充质干细胞在颅缝早闭症中的研究进展
- Author:
Yingying YUE
1
;
Xiaolei JIN
Author Information
1. 中国医学科学院北京协和医学院整形外科医院颅颌面四科，北京 100144
- Keywords:
Craniosynostoses;
Mesenchymal stem cells;
Cranial sutures;
Bone regeneration
- From:
Chinese Journal of Plastic Surgery
2023;39(9):1028-1034
- CountryChina
- Language:Chinese
-
Abstract:
Cranial suture mesenchymal stem cells are a heterogeneous population of craniofacial stem cells with self-renewal and multi-lineage differentiation capabilities. These cells play a crucial role in various physiological processes, including skull growth and development, maintenance of homeostasis, and injury repair. Previous studies on mesenchymal stem cells or skeletal stem cells have mainly focused on long bones, while relevant studies in the field of cranial bone research are quite limited. This paper provides a comprehensive summary of the discovery, extraction, and identification of cranial suture mesenchymal stem cells, along with an overview of their biological characteristics. Additionally, it reviews the latest advancements in understanding the role of cranial suture mesenchymal stem cells in the pathogenesis and treatment of craniosynostosis.
