Significance and treatment strategies of pathologic complete response after neoadjuvant therapy for gastric cancer
10.3760/cma.j.cn441530-20240425-00153
- VernacularTitle:胃癌新辅助治疗后病理完全缓解的意义及治疗策略
- Author:
Jie CHEN
1
;
Fenglin LIU
Author Information
1. 复旦大学附属肿瘤医院胃外二科 复旦大学上海医学院肿瘤学系，上海 200032
- Keywords:
Stomach neoplasms;
Neoadjuvant therapy;
Pathological complete response;
Prognosis
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(7):666-671
- CountryChina
- Language:Chinese
-
Abstract:
Neoadjuvant therapy, as an important part of comprehensive treatment for locally advanced gastric cancer, has been recommended by various guidelines. Partial locally advanced gastric cancer patients can achieve pathologic complete response (pCR) after neoadjuvant therapy, thus achieving relatively good prognosis. However, there is still controversy over whether complete remission in local pathology can translate into survival benefits, whether pCR is equivalent to cure, and whether subsequent adjuvant therapy is needed. Therefore, how to predict patients who can achieve pathologic complete response after neoadjuvant therapy and identify truly cured patients is the direction of future exploration.
