Advances in immune checkpoint inhibitor-induced cardiotoxicity
10.12025/j.issn.1008-6358.2024.20240486
- VernacularTitle:免疫检查点抑制剂相关心脏毒性研究进展
- Author:
Qingqing CAI
1
;
Leilei CHENG
Author Information
1. 复旦大学附属中山医院药剂科,上海 200032
- Keywords:
immune checkpoint inhibitor;
cardiotoxicity;
myocarditis;
monitoring
- From:
Chinese Journal of Clinical Medicine
2024;31(4):531-536
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitors(ICIs)have emerged as one of the novel immunotherapy drugs in recent years,and been approved for the treatment of multiple tumour types.However,over-activation of the immune system may lead to immune-related advese events,among these,ICIs-induced cardiotoxicity include myocarditis,pericardial disease,atherosclerosis and vasculitis.Although ICIs-induced cardiotoxicity is rare,it may lead to serious clinical complications and even death.Thus,timely identification and management of ICIs-induced cardiotoxicity is vital in clinical practice.Once diagnosed,prompt treatment is required according to the severity of the disease.Standardized prevention and treatment strategies need multidisciplinary collaboration to provide long-term individualized monitoring and management for patients.
