Risk factors of coronary slow flow and its correlation with inflammatory response based on single clinical center in China
10.12025/j.issn.1008-6358.2018.20180136
- VernacularTitle:基于单中心的冠状动脉慢血流危险因素分析及其与炎症反应的相关性
- Author:
Jian-Hua YAN
1
;
Ying-Gang SUN
;
Man-Tian CHEN
;
Yong TANG
;
Shu MENG
;
Ya-Chen ZHANG
;
Yan ZHANG
Author Information
1. 上海交通大学医学院附属新华医院心内科
- Keywords:
coronarsloflow;
correcteTIMI framcount;
risfactors;
inflammatorfactors;
matrix metalloproteinase-9
- From:
Chinese Journal of Clinical Medicine
2018;25(2):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk factors of coronary slow flow(CSF)and the role of inflammatory response on its pathogenesis.Methods:The CSF was evaluated by corrected thrombolysis in myocardial infarction(TIMI)frame count (CTFC).Totally 96 cases with CSF(CSF group)and 106 cases with normal flow(NCSF group)were selected from patients undergoing coronary angiography(CAG)in our hospital from January 2016 to December 2016.Single and multi-variable logistic regression analysis was used to assess the relationship between CSF and clinical characteristics,baseline biochemistry and related inflammation factors(both in peripheral venous blood and in coronary arterial blood)including interleukin-6(IL-6), hypersensitive C reactive protein(hsCRP)and matrix metalloproteinase-9(MMP-9).Results:The CTFC values of three branches of coronary arteria in CSF group were all significantly higher than those in control group(left anterior descending:32.3 ± 3.7 vs 17.8 ± 2.1,left circumflex branch:34.5 ± 3.9 vs 23.1 ± 2.8,right coronary artery:34.9 ± 4.3 vs 21.4 ± 3.2, all P<0.01).The most common coronary artery involved by CSF was right coronary artery(83.3%).Single factor analysis found that the body mass index,diabetes ratio,uric acid,IL-6,hsCRP in coronary arterial blood,MMP-9 in both peripheral venous and coronary arterial blood in CSF group were significantly higher than those in NCSF group(P< 0.05 or 0.01). Logistic regression analysis found that body mass index(OR= 1.313,95% CI 1.026-1.654,P= 0.034),diabetes(OR=1.604,95% CI 1.198-2.466,P=0.006),uric acid(OR=1.036,95% CI 1.006-1.102,P= 0.027),M M P-9 in peripheral venous blood(OR=2.279,95% CI 1.478-4.022,P=0.004),M M P-9 in involved coronary arterial blood(OR=3.145,95%CI 2.011-5.023,P=0.000)were independent risk factors of CSF.Conclusions:Body mass index,diabetes,and uric acid are independent risk factors of CSF.Compared with the systemic inflammatory response,local inflammatory response of the involved coronary arteries is more relevant to CSF.MMP-9 plays an important role in the pathogenesis of CSF.
