Current research on the potential application of adipose derived stem cell exosomes in hypertrophic scars and related mechanisms

VernacularTitle:脂肪干细胞外泌体在增生性瘢痕中的应用及相关机制研究进展
Author: Hongtao WANG ¹ ; Juntao HAN ; Dahai HU
Author Information

1. 空军军医大学第一附属医院全军烧伤中心烧伤与皮肤外科，西安　710032
Keywords: Adipose derived stem cells; Exosome; Hypertrophic scar; Inflammation
From: Chinese Journal of Plastic Surgery 2022;38(2):224-227
CountryChina
Language:Chinese
Abstract: Currently, there is no effective treatment for hypertrophic scars. It has been reported clinically that fat transplantation improved scar appearance, itch, pain, as well as other symptoms, and inhibited scar hyperplasia. The mechanism may be related to the regulatory effect of adipose-derived stem cells (ADSCs) on local immune inflammatory response through paracrine, and the exosome of ADSCs may play an important role in this process. Exosomes mediate signal transduction between stem cells and target cells, which have potential application in hypertrophic scars as a substitute for cells injection. In this article, recent clinical and basic researches of ADSCs exosome in scar treatment were reviewed, its clinical application prospect and research direction were proposed.