Research progress of adipose-derived stem cells in the treatment of diabetic foot ulcers

VernacularTitle:脂肪来源干细胞治疗糖尿病足溃疡的研究进展
Author: Nating XU ¹ ; Xuejun NI ; Biao WANG
Author Information

1. 福建医科大学附属第一医院整形外科　福州　350005
Keywords: Diabetes complications; Foot ulcer; Adipose tissue; Stem cells; Wound healing
From: Chinese Journal of Plastic Surgery 2022;38(2):224-229
CountryChina
Language:Chinese
Abstract: Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes. The current treatment method usually focus on blood glucose controlling, routine care, anti-infection, debridement and other aspects, but still have not achieved good result . Adipose-derived stem cells (ADSCs) possess the characteristics of a wide range of sources, easy acquisition, and low immunogenicity, making them hot topics of research area in the field of stem cell. ADSCs has become a new strategy for the treatment of DFUs . This review aims to describe the pathophysiological characteristics of diabetic foot ulcers, the advantages and biological function of ADSCs and their mechanisms of promoting DFUs wound healing, to provide a theoretical basis for the clinical application of ADSCs in the treatment of DFUs.