Guiding significance of pathological diagnosis in watch and wait strategy for locally advanced rectal cancer patients after neoadjuvant therapy
10.3760/cma.j.cn.441530-20200224-00079
- VernacularTitle:病理诊断在直肠癌新辅助治疗后等待观察策略中的指导作用
- Author:
Zhongwu LI
1
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 恶性肿瘤发病机制及转化研究教育部重点实验室 病理科 100142
- Keywords:
Rectal neoplasms;
Neoadjuvant therapy;
Pathological evaluation;
Watch and wait strategy
- From:
Chinese Journal of Gastrointestinal Surgery
2020;23(3):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Some studies have demonstrated promising results of watch and wait (W&W) approaches in carefully selected patients with locally advanced rectal cancer who get a clinical complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT). This approach of organ- preservation helps patients avoid surgery and its related morbidity and mortality. nCRT will lead to the regression of the tumor cells and the uneven distribution of the residual tumor cells. The reliability of biopsy is still unsatisfactory in W&W strategy due to the high ratio of false negative cases. Therefore, the patients with negative histopathological assessment should also receive a strict follow-up. In the future, immune microenvironment and molecular markers, patient derived organoid, circulating tumor cells (CTCs) and circulating cell-free nucleic acids (cfDNA) may be helpful for screening and monitoring patients undergoing W&W.
