Expression and Significance of Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand in Carotid Artery of Rats with Atherosclerosis
- VernacularTitle:动脉粥样硬化大鼠颈总动脉糖皮质激素诱导的肿瘤坏死因子受体配体的表达及意义
- Author:
Qiang WANG
1
;
Huimin GU
;
Kaiwen WANG
Author Information
1. 江苏省昆山市第一人民医院心血管内科
- Keywords:
Atherosclerosis;
Glucocorticoid-induced tumor necrosis factor receptor ligand;
Inflammatory reaction
- From:
Chinese Journal of Clinical Medicine
2015;(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the change in the expression of glucocorticoid‐induced tumor necrosis factor receptor ligand (GITRL) in atherosclerotic process and its significance ,by detecting the expression of GITRL in carotid artery of rats with atherosclerosis .Methods :Rat model of atherosclerosis was established and the atherosclerotic lesions were observed . The expression of GITRL in carotid artery was analyzed by immunohistochemical method and Western blotting .Results:The lipid deposition increased significantly in carotid artery of rats with atherosclerosis . The elastic fibers were incomplete and discontinuous .The endovascular expression level of GITRL was significantly higher in the carotid artery of atherosclerosis rats than that in the carotid artery of non‐atherosclerosis rats .Conclusions :As a vascular inflammatory molecule ,produced after high‐fat diet ,GITRL may become an independent risk factor for predicting the occurrence of atherosclerosis .
