Research Progress on the Role of GSDME-mediated Pyroptosis in the Treatment of Lung Cancer
10.3779/j.issn.1009-3419.2024.106.17
- VernacularTitle:GSDME介导的细胞焦亡在肺癌治疗中作用的研究进展
- Author:
LI HUAN
1
;
TANG XUDONG
Author Information
1. 524023 湛江,广东医科大学生物化学与分子生物学研究所,抗肿瘤活性物质研发协同创新中心;523808 东莞,广东医科大学医学技术学院
- Keywords:
Lung neoplasms;
Gasdermin E;
Pyroptosis
- From:
Chinese Journal of Lung Cancer
2024;27(7):529-534
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer causes a significant threat to human health.Despite considerable advancements in the treat-ment technologies in recent years,the five-year survival rate for lung cancer patients remains low.In this context,the discovery of pyroptosis,a unique cell death mechanism,offers a novel perspective for exploring new pathways of lung cancer treatment.Particularly,the role of gasdermin E(GSDME)in the process of pyroptosis reveals its tremendous potential in lung cancer therapy.Recent studies have made considerable progress in understanding the role of GSDME-mediated pyroptosis in lung cancer growth,the lung cancer microenvironment,and the effect of GSDME methylation on lung cancer treatment.This paper summarizes these research advancements and analyzes the potential and possible side effects of GSDME-mediated pyroptosis in lung cancer therapy,aiming to provide a theoretical foundation for developing more effective strategies for lung cancer treat-ment.
