Role and Mechanism of Lactylation in Cancer
10.3779/j.issn.1009-3419.2024.102.20
- VernacularTitle:乳酸化修饰在癌症中的研究进展
- Author:
ZHANG QICHENG
1
;
CAO LIMIN
;
XU KE
Author Information
1. 300052 天津,天津医科大学总医院,天津市肺癌研究所,天津市肺癌转移和肿瘤微环境重点实验室
- Keywords:
Lactate;
Lactylation;
Cancer
- From:
Chinese Journal of Lung Cancer
2024;27(6):471-479
- CountryChina
- Language:Chinese
-
Abstract:
Post translational modifications(PTMs)can change the properties of a protein by covalent addition of functional groups to one or more amino acids,and influence almost all aspects of normal cell biology and pathogenesis.Lacty-lation is a novel identified PTM,and has been found in both histone and non-histone proteins.Since associated with the end product of glycolysis--lactate,lactylation modification could provide a new perspective for understanding the relationship be-tween metabolic reprogramming and epigenetic modifications.Accumulated evidences suggest that lactylation play important roles in tumor progression and links to poor prognosis in clinical studies.Histone lactylation can affect gene expression in tu-mor cells and immunological cells,further promoting tumor progression and immune suppression.Lactylation on non-histone proteins can also regulate tumor progression and drug resistance.In this review,we aimed to summarize the roles of lactylation in cancer progression,microenvironment interactions and immune suppression,try to identify new molecular targets for can-cer therapy and provide a new direction for combined targeted therapy and immunotherapy.
