Research progress on histone methylation modification in aging cardiovascular disease

VernacularTitle:组蛋白甲基化修饰在衰老性心血管病变中的研究进展
Author: Di MENG ¹ ; Jing ZHANG ; Ping ZENG ; Li LIU ; Jingyi WU ; Yifan HUANG ; Jian YANG
Author Information

1. 三峡大学第一临床医学院/湖北省宜昌市中心人民医院心血管内科,湖北宜昌,443000;三峡大学心血管病研究所,湖北宜昌,443000;湖北省缺血性心血管疾病临床医学研究中心,湖北宜昌,443000;湖北省宜昌市中心人民医院中心实验室,湖北宜昌,443000
Keywords: histone methylation modification; myocardial aging; valves; cardiac conduction system; vascular aging; aging
From: Journal of Clinical Medicine in Practice 2023;27(23):129-134
CountryChina
Language:Chinese
Abstract: Changes in cardiac structure and function such as myocardial aging,valve alterations,alterations in the cardiac conduction system and vascular aging are crucial for studying therapeutic methods for age-related cardiovascular diseases.Histone methylation modification is involved in the regulation of gene expression and closely related to the occurrence and development of age-related car-diovascular diseases.This paper provided a comprehensive review on the role of histone methylation modification in cardiac structural and functional changes,providing new theoretical basis for age-relat-ed cardiovascular diseases.