The cell nuclear damage probably induces chronic refractory diseases
10.3760/cma.j.cn121094-20230302-00059
- VernacularTitle:细胞核损伤可能诱发慢性难治性疾病
- Author:
Maojin LI
1
;
Jue LI
;
Dongsheng NIU
Author Information
1. 北京市职业病防治研究院/北京市化工职业病防治院体检部，北京 100093
- Keywords:
Gene expression regulation;
Nuclear damage;
Abnormal nuclear cell;
Nuclear abnormality;
Chronic refractory diseases;
Cancer;
Aging;
Occupational health and o
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(8):636-640
- CountryChina
- Language:Chinese
-
Abstract:
The cell nuclear damage is mainly caused by the radiation and various carcinogenic compounds, the essence of the damage is molecular adhesion fracture and chemical modification. After nuclear damage, the cells whose nuclei may be abnormal in morphology, structure and function, then become a kind of morbid cells or defective cells. The cell nuclear damage can affect gene expression and regulation, leading to dysfunctions or abnormalities of transcription and protein synthesis, which results in aging and induces various chronic refractory diseases, such as hypertension, atherosclerosis, diabetes, Alzheimer's disease, autoimmune diseases, and so on. The cell nuclear damage can also affect the state of cell differentiation and lead to restart of genes related to division and proliferation, thus inducing cancer. The cancer cells are derived from the cells with nuclear abnormalities, and the biological behavior or characteristics of cancer cells (shedding and metastasis, immune tolerance, uncontrolled, loss of contact inhibition, etc.) are derived from cells with nuclear abnormalities. This article reviewed the chronic refractory diseases caused by nuclear damage and their mechanisms, which provided a new idea for occupational health and toxicology research, as well as a new method and strategy for occupational disease prevention and treatment.
