COVID-ONE-hi:The One-stop Database for COVID-19-specific Humoral Immunity and Clinical Parameters
- Author:
Xu ZHAOWEI
1
;
Li YANG
;
Lei QING
;
Huang LIKUN
;
Lai DAN-YUN
;
Guo SHU-JUAN
;
Jiang HE-WEI
;
Hou HONGYAN
;
Zheng YUN-XIAO
;
Wang XUE-NING
;
Wu JIAOXIANG
;
Ma MING-LIANG
;
Zhang BO
;
Chen HONG
;
Yu CAIZHENG
;
Xue JUN-BIAO
;
Zhang HAI-NAN
;
Qi HUAN
;
Yu SIQI
;
Lin MINGXI
;
Zhang YANDI
;
Lin XIAOSONG
;
Yao ZONGJIE
;
Sheng HUIMING
;
Sun ZIYONG
;
Wang FENG
;
Fan XIONGLIN
;
Tao SHENG-CE
Author Information
1. Shanghai Center for Systems Biomedicine,Key Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200240,China;Key Laboratory of Gastrointestinal Cancer(Fujian Medical University),Ministry of Education,School of Basic Medical Sciences,Fujian Medical University,Fuzhou 350122,China
- Keywords:
Protein microarray;
Humoral immunity;
One-stop tool;
Shiny
- From:
Genomics, Proteomics & Bioinformatics
2021;19(5):669-678
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19.However,differences in immune responses and clinical features among COVID-19 patients remain largely unknown.Here,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients.In addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database.Furthermore,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters.After the"START"button is clicked,one can readily obtain a comprehensive analysis report for further interpretation.COVID-ONE-hi is freely available at www.COVID-ONE.cn.
