The relationship of vitam in D receptor gene and blood lead : a meta-analysis

VernacularTitle:维生素D受体基因与血铅水平的meta分析
Keywords: Receptors,calcitriol; Lead poisoning; Polymorphism,siagle nucleotide
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2016;34(3):206-209
CountryChina
Language:Chinese
Abstract: Objective The correlation of vitamin D receptor (VDR) gene polymorphism and blood lead level had been in doult,which allowed us to write this article.Methods Relevant studies about the blood lead and VDR B/b gene polymorphism which published from 1979-2015,were searched in multiple bibliographic databases,such as:CNKI,Wanfang Database,PUBMED.Of the ten references selceted,three were divided into two groups which were classified as different researches,so there were thirteen studies in the meta-analysis.According to the level of blood lead,the studies were analyzed by three groups:normal group,low dose grou and high dose group.The analysis was performed by stata 12.0 software.Results The blood lead level of VDR B/ b genotype was significantly difference in all the three groups (P＜0.05),but there were apparent heterogeneity between normal group and low dose group (P＜0.05,I2=84.2％;P＜0.05,I2=88.9％),except the high dose group (P＞0.05,I2=12.7％);after adjusted,all showed no heterogeneity,and the results were still the same.Conclusion The genotype of VDR may be correlated with blood lead,and the levels of blood lead varied with different genetypes.