Combination therapy in cancer：effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
10.1186/s40880-016-0123-1
- Author:
Nerini Fuso ILARIA
1
;
Cesca MARTA
;
Bizzaro FRANCESCA
;
Giavazzi RAFFAELLA
Author Information
1. Department of 0ncology
- Keywords:
Combination therapies;
Angiogenesis inhibitors;
Drug delivery;
Tumor microenvironment
- From:Chinese Journal of Cancer
2016;35(12):647-656
- CountryChina
- Language:Chinese
-
Abstract:
Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation is far from clear. The most widespread explanation is enhanced delivery of therapeutics due to vascular remodeling, lower interstitial pres-sure, and increased blood lfow. While the antiangiogenic effects on vascular morphology have been fairly consistent in both preclinical and clinical settings, the improvement of tumor vessel function is debated. This review focuses on the effect of anti-VEGF therapy on tumor microenvironment morphology and functions, and its therapeutic beneifts when combined with other therapies. The uptake and spatial distribution of chemotherapeutic agents into the tumor after anti-VEGF are examined.
