Relapse ofboth small cell lung cancer andLambert-Eaton myasthenic syndrome aftera 13-year disease-free survival period
10.1186/s40880-016-0127-x
- Author:
FumioAsano
1
;
KeisukeWatanabe
;
MasaharuShinkai
;
YoshitakaTei
;
KeiMishina
;
MikikoTanabe
;
HiroshiIshii
;
MasahiroShinoda
;
TadasukeShimokawaji
;
MakotoKudo
;
TakeshiKaneko
Author Information
1. Respiratory Disease Center
- Keywords:
Lambert-Eaton myasthenic syndrome;
Paraneoplastic syndrome;
Paraneoplastic neurological syndrome;
P/Q-type anti-voltage-gated calcium channel antibody;
Small cell lung carcinoma
- From:Chinese Journal of Cancer
2016;56(11):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Lambert–Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10years is rare. We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC (cT0N2M0, stage IIIA) 13years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period.
