Association ofmicroRNA polymorphisms withthe risk ofhead andneck squamous cell carcinoma ina Chinese population:a case-control study
- Author:
LiminMiao
1
;
LihuaWang
;
LongbiaoZhu
;
JiangboDu
;
XunZhu
;
YumingNiu
;
RuixiaWang
;
ZhibinHu
;
NingChen
;
HongbingShen
;
HongxiaMa
Author Information
1. Jiangsu Key Laboratory of Oral Diseases
- Keywords:
Head and neck cancer;
microRNA;
Polymorphism;
Squamous cell carcinoma;
Susceptibility
- From:Chinese Journal of Cancer
2016;56(11):596-603
- CountryChina
- Language:Chinese
-
Abstract:
Background:MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miR-NAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population. Methods:In this study, we genotyped ifve common single-nucleotide polymorphisms (SNPs) in several key miRNAs (miR-149 rs2292832,miR-146a rs2910164,miR-605 rs2043556,miR-608 rs4919510, andmiR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case–control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population. Results:The results revealed thatmiR-605 rs2043556 [dominant model: adjusted odds ratio (OR) 0.71, 95% conif-dence interval (CI) 0.58–0.88; additive model: adjusted OR 0.74, 95% CI 0.62–0.89] andmiR-196a2 rs11614913 (domi-nant model: adjusted OR 1.36, 95% CI 1.08–1.72; additive model: adjusted OR 1.28, 95% CI 1.10–1.48) were signiifcantly associated with the risk of oral squamous cell carcinoma (OSCC). Furthermore, when these two loci were evaluated together based on the number of putative risk alleles (rs2043556 A and rs11614913 G), a signiifcant locus-dosage effect was noted on the risk of OSCC (Ptrend<0.001). However, no signiifcant association was detected between the other three SNPs (miR-149 rs2292832,miR-146a rs2910164, andmiR-608 rs4919510) and HNSCC risk. Conclusion:Our study provided the evidence thatmiR-605 rs2043556 andmiR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.
