Prognostic factors affecting postoperative survival ofpatients withsolitary small hepatocellular carcinoma
10.1186/s40880-016-0143-x
- Author:
MuYanCai
1
;
FengWeiWang
;
ChangPengLi
;
LiXuYan
;
JieWeiChen
;
RongZhenLuo
;
JingPingYun
;
YiXinZeng
;
DanXie
Author Information
1. State Key Laboratory of Oncology in South China
- Keywords:
Small hepatocellular carcinoma;
Tumor size;
Vascular invasion;
Prognosis
- From:Chinese Journal of Cancer
2016;35(10):528-534
- CountryChina
- Language:Chinese
-
Abstract:
Background:Small hepatocellular carcinoma (sHCC) is a unique variant of HCC that is characterized by small tumor size (maximum tumor diameter≤3cm) and favorable long?term outcomes. The present study aimed to deifne clin?icopathologic factors that predict survival in patients with sHCC.
Methods:The study population consisted of 335 patients who underwent hepatectomy for solitary sHCC between December 1998 and 2010. Prognostic factors were evaluated using Kaplan–Meier curves and Cox proportional hazard models.
Results:The 5?year overall survival (OS) and recurrence?free survival (RFS) rates were 77.7% and 59.9%, respectively. Kaplan–Meier curves showed that tumor size and vascular invasion had prognostic signiifcance within this relatively selected cohort (P<0.05). Multivariate analysis conifrmed that increased tumor size and vascular invasion were independent prognostic factors for short OS (hazard ratio [HR]=2.367, 95% conifdence interval [CI] 1.406–3.985; HR=2.954, 95% CI 1.781–4.900) and RFS (HR=1.779, 95% CI 1.259–2.514; HR=1.699, 95% CI 1.165–2.477) in sHCC patients (P<0.05). Importantly, a proposed prognostic scoring model was derived according to the two variables; tumor size and extent of vascular invasion were signiifcantly associated with OS and RFS in patients with sHCC (P<0.001).
Conclusions:Tumor size and vascular invasion are feasible and useful prognostic factors for sHCC. The proposed prognostic model, based on tumor size and vascular invasion, is informative in predicting survival in sHCC patients undergoing hepatectomy.
