Forty-six cases ofnasopharyngeal carcinoma treated with50Gy radiotherapy plushematoporphyrin derivative：20years offollow-up andoutcomes fromthe Sun Yat-sen University Cancer Center
10.1186/s40880-016-0098-y
- Author:
BingQingXu
1
;
ZiWeiTu
;
YaLanTao
;
ZhiGangLiu
;
XiaoHuiLi
;
WeiYi
;
ChangBingJiang
;
YunFeiXia
Author Information
1. State Key Laboratory of Oncology in South China
- Keywords:
Low-dose radiotherapy;
Nasopharyngeal carcinoma;
Radiosensitivity;
Quality of life
- From:Chinese Journal of Cancer
2016;35(6):317-326
- CountryChina
- Language:Chinese
-
Abstract:
Background:With the improved overall survival (OS) of nasopharyngeal carcinoma (NPC) patients, the importance of quality of life (QoL) is increasingly being recognized. For some radiosensitive NPC patients, whether low?dose radio?therapy can improve the QoL without affecting clinical effcacy is unknown. This study aimed to assess the survival rates and QoL of NPC patients treated with 50Gy radiotherapy plus hematoporphyrin derivative (HPD). Methods:Forty?six newly diagnosed NPC patients treated with 50Gy radiotherapy plus HPD between June 1988 and July 1992 were analyzed. All patients were restaged according to the 7th edition of the American Joint Commit?tee on Cancer staging system. The radiotherapy plan was designed on the basis of pretreatment computed tomog?raphy. The OS, local recurrence?free survival (LRFS), distant metastasis?free survival (DMFS), and disease?free survival (DFS) rates were estimated using the Kaplan–Meier method. QoL was assessed using the Late Radiation Morbidity Scoring Criteria of the Radiation Therapy Oncology Group. Results:The 5?year OS, LRFS, DMFS, and DFS rates were 74.3%, 72.6%, 82.1%, and 61.2%, respectively. The corre?sponding 10?year rates were 38.4%, 62.9%, 78.5%, and 49.8%, respectively, and the 20?year rates were 27.7%, 51.4%, 78.5%, and 40.7%, respectively. None of the patients developed severe radiation?related complications, such as radiation?induced temporal lobe necrosis, hearing loss, trismus, and dysphagia. Conclusion:Some NPC patients were sensitive to 50Gy radiotherapy plus HPD, and this sensitivity was characterized by long?term survival without signiifcant late treatment morbidities.
