Twenty years after：the beautiful hypothesis andthe ugly facts
10.1186/s40880-016-0087-1
- Author:
FrancescoPezzella
1
;
KevinGatter
;
ChaoNanQian
Author Information
1. Nuffield Division of Clinical Laboratory Science
- Keywords:
Angiogenesis;
Vasculogenic mimicry;
Vessel co-option;
Treatment resistance;
Targeted therapy
- From:Chinese Journal of Cancer
2016;(2):55-57
- CountryChina
- Language:Chinese
-
Abstract:
The limited clinical beneifts from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between vessels and cancer. Tumors need blood perfusion but there are mounting evidences that angiogenesis alone does not explain it in all the neoplasms. In this editorial, for a special issue on tumor and vessels published in theChinese Journal of Cancer, we brielfy introduce the history of the evidences that solid tumors can sometimes obtain blood perfusion by alter?native approaches other than sprouting angiogenesis, i.e., vessel co?option and vasculogenic mimicry. This editorial provides also the links to several most recently published discoveries and hypotheses on tumor interaction with blood vessels.
