Vascular endothelial growth factor(VEGF)-D in association with VEGF receptor-3 in lymphatic metastasis of breast cancer
10.3321/j.issn:1000-467X.2009.12.019
- VernacularTitle:血管内皮生长因子D及其受体3在乳腺癌淋巴转移中作用的研究进展
- Author:
Chen YA-NING
1
;
Gu YAN
Author Information
1. 上海交通大学医学院附属第九人民医院
- Keywords:
breast neoplasm;
lymphangiogenesis;
vascular endothelialgrowth factor-D;
vascular endothelial growth factor receptor-3
- From:Chinese Journal of Cancer
2009;28(12):1337-1343
- CountryChina
- Language:Chinese
-
Abstract:
Breast carcinoma is the most common malignant tumor in women.For these patients, lymph node metastasis is one of the most important prognostic factors. Recent studies suggest that lymphangiogenesis can contribute to the Iymphatic metastasis in tumors.Several members of vascular endothelial growth factor(VEGF)family,such as VEGF-C,VEGF-D,and VEGF receptor-3(VEGFR-3),have been found to promote lymphangiogenesis in breast cancer.However.there are still some controversy about the prognostic value of VEGF-D and the relation between VEGFR-3 and lymphangiogenesis.This article tried to provide an overview of the research progress of lymphangiogenic factor VEGF-D and its receptor VEGFR-3 in lymphatic metastasis of breast cancer.
