Decreased KAI-1 expression in advanced renal cell carcinoma
10.3321/j.issn:1000-467X.2000.06.014
- VernacularTitle:KAI-1基因在晚期肾癌中表达降低
- Keywords:
Kidney neoplasms;
KAI-1;
Metastasis
- From:Chinese Journal of Cancer
2000;19(6):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of KAI-1 mRNA in renal cell carcinoma and the relationship with the metastasis. Method: RT-PCR was used to detect KAI-1 mRNA expression in specimens from 35 cases with renal cancer and adjacent normal kidney tissues. Results: KAI-1 expression rate in renal cancer was significantly lower than that in normal kidney tissues (P< 0.05); tumors of patients with extrarenal invasion or regional lymph node metastasis (stage Ⅲ orⅣ ) had significantly lower KAI-1 expression levels than tumors of patients with stage Ⅰ or Ⅱ disease (P< 0.05).Conclusion: Decreased expression of the KAI-1 gene may be related to disease progression in patients with renal cancer.
