Clinical significance of E-cadherin expression in gastric cancer
10.3321/j.issn:1000-467X.2000.01.017
- VernacularTitle:E-钙粘附素在胃癌表达的临床意义
- Keywords:
Gastric neoplasm;
E-cadherin;
Prognosis;
Dysplasia
- From:Chinese Journal of Cancer
2000;19(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of the expression of E-cadherin (E-CD) in carcinogenesis and progre-ssion of gastric cancer.Methods:The E-CD expression was studied immunohistochemistrically in 20 specimens of normal gastric mucosa, 101 Ro-resected gastric carcinomas and 43 of dysplasimucosa surrounding tumors. Results: The normal and dysplastic gastric mucosae strongly expressed E-CD, whereas 88.1% (89/101) gastric cancers showed reduced or no expression of E-CD. The significant relationship was observed between low E-CD expression and cellular dedifferentiation and infiltrative groth pattern (P<0.05). The 3 and 5-year survival rates of patients with normal E-CD expression were significantly higher than those of patients with reduced or negative expression (P< 0.05).Conclusion:The decreased expression of E-CD might be responsible for the cellular dedifferentiation, the infiltrative growth and poor prognosis of gastric carcinomas.
