Investigate the incidence of anemia and its effect for prediction 1-year mortality in HBV related decompensated cirrhosis patients
10.3760/cma.j.cn112866-20200923-00252
- VernacularTitle:HBV感染肝硬化失代偿期患者贫血情况调查及其对预后的影响
- Author:
Fanrong JIANG
1
;
Huadong YAN
Author Information
1. 中国科学院大学宁波华美医院药剂科 315010
- Keywords:
Decompensation of hepatitis B cirrhosis;
Anemia;
Risk factors;
Survival analysis
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(5):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence and severity of anemia and its effect on one-year survival in HBV related decompensated cirrhosis patients (HBV-DC).Methods:647 consecutive HBV-DC patients were prospectively enrolled from January 2016 to December 2018 in Hwamei Hospital, University of Chinese Academy of Sciences. Anemia and the baseline characterics of patients were evaluated. Cox regression analysis was used to evaluate the impact on one-year survival.Results:Of 647 HBV-DC patients, 406 were complicated with anemia, accounting for 62.8% of the total population, including 254 patients with mild anemia (39.3%), 122 with moderate anemia (18.9%), and 30 with severe anemia (4.6%). 133 died in 1 year, with a mortality rate of 20.6%. On cox regression analysis, age ( HR, 1.033; 95% CI, 1.017-1.049), hemoglobin ( HR, 0.992; 95% CI, 0.985-0.999), WBC ( HR, 1.069; CI, 1.028-1.111), MELD score ( HR, 1.095; 95% CI, 1.070-1.120) were independent associated with 1-year mortality. The 1-year survival KM curve of anemia and its severity was significantly different ( P<0.001). Conclusions:The incidence of anemia in HBV-DC patients is as high as 62.8%. Anemia and its severity are important factors affecting the one-year prognosis of HBV-DC patients, which provide new ideas for clinical evaluation and prognosis assessment.
