Association between maternal immune activation and neurodevelopmental disorders in children

VernacularTitle:母体免疫激活与儿童神经发育障碍
Author: Fengyu YANG ¹ ; Fangbiao TAO
Author Information

1. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室人口健康与优生安徽省重点实验室/国家卫生健康委配子及生殖道异常研究重点实验室，合肥　230032
Keywords: Maternal immune activation; Neurodevelopmental disorder; Epidemiology
From: Chinese Journal of Epidemiology 2023;44(9):1491-1496
CountryChina
Language:Chinese
Abstract: During pregnancy, as a special period, mother is vulnerable to adverse exposure, affecting the health of offspring. Maternal immune activation (MIA) due to maternal immune imbalance during pregnancy can affect the neurodevelopment of offspring. Evidence from epidemiological studies and animal studies supports an association between MIA and neurodevelopmental disorders (NDDs) in offspring. A variety of factors, such as genetic background, maternal nutritional status and maternal gut microbes, can influence the strength of the association. Studies have shown that MIA affects synapsis formation and pruning in offspring through a variety of pathways, and the placenta also plays a role in such association. This article summarizes the recent research of the association between MIA and neurodevelopmental disorders in children, and provides suggestion for the prevention of the incidence of NDDs.