Metabolism of Deltamethrin in Rats
- Author:
S.EL-MAGHRABY
1
Author Information
1. Department of Applied Organic Chemistry National Research Centre
- Keywords:
Pyrethroid insecticide 14C-deltamethrin;
Oral and intraperitoneally treatment;
Bioavailability
- From:
Biomedical and Environmental Sciences
2007;20(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the membolism of 14C-deltamethrin in rats. Methods Rats were dosed orally and i.p.with a single dose of 14C-deltamethrin(0.64 mg/Kg)body weight.The required dose was applied daily for 3 days.At the end of the experiment,selected organs,such as liver,kidney,fat,intestine,and blood were excised for radioassay of 14C-content.Results Deltamethrin was almost eliminated from the body within 1-3 days.The main portion of 14C-residues Was extracted from urine(38%,32%)and feces(20%,24%)with a little amount remained in various organs. Conclusion The elimination and distribution of 14C-radioactivity in rats treated orally and intraperitoneally signify th6at deltamethrin is bioavailable in urine and feces.
