Association between hemoglobin level and increased heart rate among people aged 60 years or above in China
10.3760/cma.j.cn112338-20220519-00434
- VernacularTitle:我国60岁及以上老年人血红蛋白与心率增快的关联研究
- Author:
Xiao ZHANG
1
;
Mei ZHANG
;
Chun LI
;
Zhengjing HUANG
;
Mengting YU
;
Limin WANG
Author Information
1. 中国疾病预防控制中心慢性非传染性疾病预防控制中心慢病危险因素监测室，北京 100050
- Keywords:
Elderly;
Hemoglobin;
Increased heart rate;
U-shaped association
- From:
Chinese Journal of Epidemiology
2023;44(2):214-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association between hemoglobin level and increased heart rate among the Chinese elderly.Methods:The study subjects were those 60 years or above and participated in the 2018 of China Chronic Disease and Risk Factor Surveillance. According to the hemoglobin level used to define anemia severity and corresponding tertiles among non-anemia, men and women were separately categorized into five groups. Multivariable logistic regression of increased heart rate on hemoglobin groups was performed, with confounders and intracluster correlation taken into account. Additionally, a restricted cubic spline was employed to interrogate their dose-response relationship.Results:A total of 71 409 elderly were finally included in the analysis. The weighted mean of hemoglobin concentration and heart rate was (142.6±17.7) g/L and (78.5±12.2) times/minute, respectively. In comparison to men with hemoglobin concentration between 130 and 147 g/L or women between 120 and 133 g/L, the odds ratio ( OR) of increased heart rate were 1.39 (95% CI: 1.17-1.64), 1.10 (95% CI: 0.99-1.21), 1.16 (95% CI: 1.09-1.23), and 1.42 (95% CI: 1.33-1.51) for men with a hemoglobin concentration of <110, 110-129, 148-158, and ≥159 g/L, respectively, and was 1.17 (95% CI: 1.02-1.33), 1.02 (95% CI: 0.93-1.12), 1.13 (95% CI: 1.07-1.19), and 1.40 (95% CI: 1.32-1.48) for women with a hemoglobin concentration of <110, 110-119, 134-142, and ≥143 g/L, respectively. Higher odds of increased heart rate associated with a hemoglobin concentration of <110 g/L were only observed among men aged 60-74 years ( OR=1.41, 95% CI: 1.15-1.73) and non-obese women ( OR=1.22, 95% CI: 1.07-1.40) but not their counterparts. The results from restricted cubic spline suggested that hemoglobin concentration, as a continuous variable, showed a U-shaped association with odds of increased heart rate. Conclusions:Lower and higher hemoglobin levels were positively associated with the risk of increased heart rate among the Chinese elderly. Maintaining hemoglobin levels within a specific range may be helpful for the management of heart rate, which in turn reduces the burden of cardiovascular diseases among older adults.
