Application of test-negative design in vaccine efficacy evaluation
10.3760/cma.j.issn.0254-6450.2020.02.024
- VernacularTitle:检测阴性设计在疫苗效果评价中的应用
- Author:
Li ZHANG
1
;
Pengfei JIN
;
Jingxin LI
;
Fengcai ZHU
Author Information
1. 南京医科大学公共卫生学院全球健康中心
- Keywords:
Test-negativedesign;
Vaccine;
Efficacy evaluation
- From:
Chinese Journal of Epidemiology
2020;41(2):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Vaccine efficacy can be assessed by a randomized placebo-control trial prior to marketing.However,after the marketing of a vaccine,if a placebo-randomized control trial is used to evaluate the efficacy of the vaccine,ethical issues will arise.Therefore,the evaluation of the efficacy of a vaccine after marketing has become a difficult problem in the public health field.In recent years,the research method of test-negative design has been widely used in the world for the evaluations of the efficacies of different post-marketing vaccines,such as influenza vaccine,rotavirus vaccine,cholera vaccine,pneumonia vaccine and EV71 vaccine.However,there are limited reports in the domestic literature on the test-negative design.Therefore,we summarize the basic principles,application steps,advantages and disadvantages of the test-negative design to provide theoretical methods and basis for the future study of test-negative design in China.
